Fireworks CS6 was working normally for me on earlier Windows Tech Preview releases, but some time after I've upgraded it to build 10041, I found out that using the align panel makes it throw errors or stop working altogether. The most often displayed message was:
Fireworks unexpected exception: 80000004.
I've learned that the align panel extension is an SFW file that runs ActionScript functions. At first I thought that my problem could be then caused by some update of the Flash Player addon that comes bundled with Internet Explorer, but further research revealed that Fireworks and other older Adobe programs actually install and use their own embedded version of Flash, the authplay.dll file.
I'm still not sure if this issue has really been caused by some design change on Windows 10041 or some setting I've manually changed, but the only workaround I've found was to install an old version of the align panel. It took me a while to find it, but it's working.